Application
Immunohistochemistry staining of PAEL receptor in brain cortex tissue using PAEL receptor Antibody.| Product Name | PAEL Receptor Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GPR37, EDNRBL, ETBR-LP-1, Gpcr/cns1, HET(B)R-LP, Het-b-r-lp, PAELR, Pael receptor |
| Product description | GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death. |
| Immunogen | PAEL Receptor antibody was raised against a peptide located in the N-Terminal extracellular domain of PAEL Receptor (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHC |
| PAEL Receptor antibody can be used in ELISA, and immunohistochemistry starting at 10 μg/mL.: |
|
| Species Reactivity | GibbonGorillaHuman |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GPR37 |
|---|---|
| Alternative Names | GPR37 EDNRBL ETBR-LP-1 Gpcr/cns1 HET(B)R-LP Het-b-r-lp PAELR Pael receptor |
| Tissue Specificity | BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Application
Immunohistochemistry staining of PAEL receptor in brain cortex tissue using PAEL receptor Antibody.| Application Notes | PAEL Receptor antibody can be used in ELISA, and immunohistochemistry starting at 10 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | PAEL Receptor antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.1% sodium azide. |
