PAX2 encodes paired box gene 2, one of many human
homologues of the Drosophila melanogaster gene prd. The central
feature of this transcription factor gene family is the conserved
DNA-binding paired box domain. PAX2 is believed to be a target of
transcriptional supression by the tumor supressor gene WT1.
Mutations within PAX2 have been shown to result in optic nerve
colobomas and renal hypoplasia. Alternative splicing of this gene
results in multiple transcript variants.1) Monte, N.M., et al. Cancer Res. 70(15):6225-6232(2010)
Immunogen
This PAX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of human PAX2.
Western Blot at 1:1000 dilution + MCF-7 whole cell lysate Lysates/proteins at 20 ug per lane.
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.