Application
Western blot analysis of extracts from 293 cells treated with Serum using Phospho-PDCD4 (Ser457) Antibody. The lane on the right is treated with the antigen-specific peptide.| Product Name | PDCD4 (phospho Ser457) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | neoplastic transformation inhibitor |
| Product description | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA1) Kakade D, Islam N, Maeda N, Adegoke OA (2014) BMC Cell Biol 15, 2. Wippich F, et al. (2013)Cell 152, 791-805 . LaRonde-LeBlanc N, et al. (2007)Mol Cell Biol 27, 147-56. |
| Immunogen | PDCD4 (phospho Ser457) antibody was raised against a peptide sequence around phosphorylation site of serine 457 (F-V-S (p)-E-G) derived from Human PDCD4 . |
| Modification | p-Ser457 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PDCD4 |
|---|---|
| Alternative Names | neoplastic transformation inhibitor |
| Molecular Weight(MW) | 51 kDa |
| Tissue Specificity | The antibody detects endogenous level of PDCD4 only when phosphorylated at serine 457. |
| Entrez Gene | 27250 |
|---|---|
| Protein Accession | NP_001186421.1 |
Application
Western blot analysis of extracts from 293 cells treated with Serum using Phospho-PDCD4 (Ser457) Antibody. The lane on the right is treated with the antigen-specific peptide.| Application Notes | Western Blot: 1:500~1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
