Application
Immunohistochemistry staining of PDCD4 in breast tissue using PDCD4 Antibody.| Product Name | PDCD4 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PDCD4, H731, Nuclear antigen H731-like, Nuclear antigen H731, Protein 197/15a |
| Product description | Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphorylation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in he ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun. |
| Immunogen | PDCD4 antibody was raised against amino acids 238 - 252 of PDCD4 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| PDCD4 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 5 μg/mL.: |
|
| Species Reactivity | HumanMouseRatXenopus |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PDCD4 |
|---|---|
| Alternative Names | PDCD4 H731 Nuclear antigen H731-like Nuclear antigen H731 Protein 197/15a |
| Tissue Specificity | pSer457 |
Application
Immunohistochemistry staining of PDCD4 in breast tissue using PDCD4 Antibody.| Application Notes | PDCD4 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 5 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store PDCD4 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
