This gene encodes a member of the POU protein family
characterized by the presence of a bipartite DNA binding domain,
consisting of a POU-specific domain and a homeodomain, separated by
a variable polylinker. The DNA binding domain may bind to DNA as
monomers or as homo- and/or heterodimers, in a sequence-specific
manner. The POU family members are transcriptional regulators, many
of which are known to control cell type-specific differentiation
pathways. This gene is a tumor suppressor involved in Wilms tumor
(WT) predisposition. Alternatively spliced transcript variants
encoding distinct isoforms have been found for this gene.1) Anney, R., et al. Hum. Mol. Genet. 19(20):4072-4082(2010)
Immunogen
This POU6F2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-61 amino acids from the N-terminal region of human POU6F2.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.