Cyclic AMP-dependent protein kinase A (PKA) is an
essential enzyme in the signaling pathway of the second messenger
cAMP. Through phosphorylation of target proteins, PKA controls many
biochemical events in the cell including regulation of metabolism,
ion transport, and gene transcription. The PKA holoenzyme is
composed of 2 regulatory and 2 catalytic subunits and dissociates
from the regulatory subunits upon binding of cAMP.[supplied by
OMIM].1) Silva, L.K., et al. Eur. J. Hum. Genet. (2010) In press :
Immunogen
This PRKAR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human PRKAR1B.
Western blot analysis in CEM cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.