Application
Western blot analysis of PRL3 Antibody in mouse heart tissue lysates (35ug/lane)| Product Name | PRL3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Protein tyrosine phosphatase type IVA 3, PRL-R, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PRL-3, PTP4A3, PRL3 |
| Product description | The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver. Its expression in colorectal cancers may contribute to the establishment of liver metastasis. In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.1) Kato,H., et al. Clin. Cancer Res. 10 (21), 7318-7328 (2004) |
| Immunogen | This PRL3 antibody is generated from rabbits immunized with a recombinant protein encoding full length of human PRL3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Gene Symbol | PTP4A3 |
|---|---|
| Alternative Names | Protein tyrosine phosphatase type IVA 3 PRL-R Protein-tyrosine phosphatase 4a3 Protein-tyrosine phosphatase of regenerating liver 3 PRL-3 PTP4A3 PRL3 |
| Molecular Weight(MW) | 20 kDa |
Application
Western blot analysis of PRL3 Antibody in mouse heart tissue lysates (35ug/lane)| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
