The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP contains an N-terminal
noncatalytic domain similar to that of band 4.1 superfamily
cytoskeleton-associated proteins, which suggested the membrane or
cytoskeleton localization of this protein. It appears to regulate
lymphatic development in mammals, and a loss of function mutation
has been found in a kindred with a lymphedema-choanal atresia.1) Au, A.C., et al. Am. J. Hum. Genet. 87(3):436-444(2010)
Immunogen
This PTPN14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 862-890 amino acids from the C-terminal region of human PTPN14.
Western blot analysis in mouse bladder tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.