Application
Immunohistochemistry staining of PTPRC in spleen, lymphocytes tissue using PTPRC Antibody.| Product Name | PTPRC Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PTPRC, B220, CD45R, CD45, gp180, Leukocyte common antigen, L-CA, Leucocyte common antigen, LY5, T200, T200 glycoprotein, T200 leukocyte common antigen, CD45 antigen, LCA |
| Product description | CD45 is a family of high-molecular weight glycoproteins uniquely expressed on the surface of all leukocytes and their hematopoietic progenitors. The CD45 family consists of multiple members that are all products of a single gene. Structurally, CD45 is composed of one fibronectin extracellular domain, one transmembrane domain, and two cytoplasmic tyrosine phosphatase domains. It is essential for B- and T-cell activation. For both cell-types, CD45 has been shown to interact with kinases including Lyn, src family kinase Lck, and Janus-family kinases. In T cells, CD45 is required for the initiation of receptor signaling by dephosphorylating a negative regulatory tyrosine in the C-terminal tail of Lck. CD45 may also negatively regulate Lck by dephosphorylating the tyrosine in the activation loop, thereby attenuating Lck activity. |
| Immunogen | PTPRC antibody was raised against a peptide located near the internal domain of PTPRC (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHC |
| PTPRC antibody can be used in immunohistochemistry starting at 0.5 - 1 μg/mL.: |
|
| Species Reactivity | GorillaHuman |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PTPRC |
|---|---|
| Alternative Names | PTPRC B220 CD45R CD45 gp180 Leukocyte common antigen L-CA Leucocyte common antigen LY5 T200 T200 glycoprotein T200 leukocyte common antigen CD45 antigen LCA |
| Tissue Specificity | BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Application
Immunohistochemistry staining of PTPRC in spleen, lymphocytes tissue using PTPRC Antibody.| Application Notes | PTPRC antibody can be used in immunohistochemistry starting at 0.5 - 1 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | PTPRC antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.1% sodium azide. |
Data sheet for OM289230