The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP possesses an extracellular
region, a single transmembrane region, and two tandem
intracytoplasmic catalytic domains, and thus represents a
receptor-type PTP. The extracellular region of this PTP contains a
carbonic anhydrase-like (CAH) domain, which is also found in the
extracellular region of PTPRBETA/ZETA. This gene is located in a
chromosomal region that is frequently deleted in renal cell
carcinoma and lung carcinoma, thus is thought to be a candidate
tumor suppressor gene.1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Immunogen
This PTPRG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 671-700 amino acids from the Central region of human PTPRG.
Western blot analysis in mouse lung tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.