Poliovirus receptor, Nectin-like protein 5, NECL-5, CD155, PVR, PVS
Product description
The protein encoded by this gene is a transmembrane
glycoprotein belonging to the immunoglobulin superfamily. The
external domain mediates cell attachment to the extracellular
matrix molecule vitronectin, while its intracellular domain
interacts with the dynein light chain Tctex-1/DYNLT1. The gene is
specific to the primate lineage, and serves as a cellular receptor
for poliovirus in the first step of poliovirus replication.
Multiple transcript variants encoding different isoforms have been
found for this gene.1) Nakai, R., et al. Cancer Sci. 101(5):1326-1330(2010)
Immunogen
This PVR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-342 amino acids from the C-terminal region of human PVR.
Western blot analysis in K562 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.