Application
Immunohistochemistry staining of RELA in placenta tissue using RELA Antibody.| Product Name | RELA Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RELA, NF-kappa-B p65delta3, NFKB3, p65, Transcription factor p65 |
| Product description | NFKB1 or NFKB2 bind to REL, RELA, or RELB to form the NFKB complex. The NFKB1/RELA heterodimer is the most abundant form of NFKB. The NFKB complex is inactivated by I-kappa-B proteins that keep it trapped in the cytoplasm. Phosphorylation of serine residues on the I-kappa B proteins mark them for ubiquitination and destruction, and NFKB translocates to the nucleus where it binds DNA. Transforming protein Tax inhibits p53 transcriptional activity through the NFKB signaling pathway, specifically via the p65 (RelA) subunit. The inhibition of p53 activity is dependent upon phosphorylation of p65 (RelA) at ser536 by the upstream kinase IKKB. |
| Immunogen | RELA antibody was raised against amino acids surrounding Ser 536 of RELA (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| RELA antibody can be used in ELISA, Western Blot starting at 1:500 - 1:2000, and immunohistochemistry starting at 1:200.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | RELA |
|---|---|
| Alternative Names | RELA NF-kappa-B p65delta3 NFKB3 p65 Transcription factor p65 |
| Tissue Specificity | pSer536 |
Application
Immunohistochemistry staining of RELA in placenta tissue using RELA Antibody.| Application Notes | RELA antibody can be used in ELISA, Western Blot starting at 1:500 - 1:2000, and immunohistochemistry starting at 1:200.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store RELA antibody at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. |
