Application
Western blot analysis of anti-ROR2 Antibody in K562 cell line lysates (35ug/lane)Application
Formalin-fixed and paraffin-embedded human brain tissue reacted with ROR2 antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.| Product Name | ROR2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Tyrosine-protein kinase transmembrane receptor ROR2, Neurotrophic tyrosine kinase, receptor-related 2, ROR2, NTRKR2 |
| Product description | ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.1) Afzal, A.R., et al., Nat. Genet. 25(4):419-422 (2000). Oldridge, M., et al., Nat. Genet. 24(3):275-278 (2000). van Bokhoven, H., et al., Nat. Genet. 25(4):423-426 (2000). Schwabe, G.C., et al., Am. J. Hum. Genet. 67(4):822-831 (2000). Masiakowski, P., et al., J. Biol. Chem. 267(36):26181-26190 (1992). |
| Immunogen | This ROR2 antibody is generated from rabbits immunized with a recombinant protein of human ROR2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | ROR2 |
|---|---|
| Alternative Names | Tyrosine-protein kinase transmembrane receptor ROR2 Neurotrophic tyrosine kinase receptor-related 2 ROR2 NTRKR2 |
| Molecular Weight(MW) | 105 kDa |
Application
Western blot analysis of anti-ROR2 Antibody in K562 cell line lysates (35ug/lane)
Application
Formalin-fixed and paraffin-embedded human brain tissue reacted with ROR2 antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.| Application Notes | For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
