The lysosphingolipid sphingosine 1-phosphate (S1P)
regulates cell proliferation, apoptosis, motility, and neurite
retraction. Its actions may be both intracellular as a second
messenger and extracellular as a receptor ligand. S1P and the
structurally related lysolipid mediator lysophosphatidic acid (LPA)
signal cells through a set of G protein-coupled receptors known as
EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P
receptors; others (e.g., EDG2; MIM 602282) are LPA
receptors.1) Chang, C.L., et al. Am. J. Physiol., Cell Physiol. 297 (2), C451-C458 (2009) :
Immunogen
This S1PR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219-247 amino acids from the Central region of human S1PR5.
Western blot analysis in A549 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.