This gene encodes a component of the
dystrophin-glycoprotein complex (DGC), which is critical to the
stability of muscle fiber membranes and to the linking of the actin
cytoskeleton to the extracellular matrix. Its expression is thought
to be restricted to striated muscle. Mutations in this gene result
in type 2D autosomal recessive limb-girdle muscular dystrophy.
Multiple transcript variants encoding different isoforms have been
found for this gene.1) Mendell, J.R., et al. Ann. Neurol. 68(5):629-638(2010)
Immunogen
This SGCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-266 amino acids from the Central region of human SGCA.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.