Application
Immunohistochemistry staining of SIRT7 in kidney tissue using SIRT7 Antibody.| Product Name | SIRT7 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | SIRT7 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones. |
| Immunogen | A mixture of synthetic peptides corresponding to amino acids 35-51 and 361-377 of human SIRT7. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| SIRT7 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 2.5 μg/mL. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | SIRT7 |
|---|---|
| Alternative Names | SIRT7 SIR2L7 Sirtuin type 7 SIR2-like protein 7 Sir2-related protein type 7 Sirtuin 7 |
| Tissue Specificity | There is no corresponding 40 kD band seen in mouse or rat liver cell lysate. |
Application
Immunohistochemistry staining of SIRT7 in kidney tissue using SIRT7 Antibody.| Application Notes | SIRT7 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 2.5 μg/mL. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | SIRT7 antibody should be stored long term (months) at -20 ˚C and short term (weeks) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.2% gelatin, 0.05% sodium azide. |
