SLAM family member 6, Activating NK receptor, NK-T-B-antigen, NTB-A, CD352, SLAMF6, KALI
Product description
The protein encoded by this gene is a type I transmembrane
protein, belonging to the CD2 subfamily of the immunoglobulin
superfamily. This encoded protein is expressed on Natural killer
(NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation
and associates with the Src homology 2 domain-containing protein
(SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs).
It functions as a coreceptor in the process of NK cell activation.
It can also mediate inhibitory signals in NK cells from X-linked
lymphoproliferative patients. Alternative splicing results in
multiple transcript variants encoding distinct isoforms.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This SLAMF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 amino acids from the C-terminal region of human SLAMF6.
Western blot analysis in T47D cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.