Application
Immunohistochemistry staining of SMAD2 in placenta tissue using SMAD2 Antibody.| Product Name | SMAD2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | SMAD2 is an intracellular protein belonging to the Dwarfin (DWA/B)/SMAD family. SMAD2 associates with SMAD4 for translocation to nucleus. It acts as an intracellular mediator of TGFbeta family of cytokines and activin type 1 receptor (ACVR1C). Hence it regulates multiple cellular processes like cell growth, proliferation, differentiation, and apoptosis and also cooperates with transcription factors to regulate expression of defined genes. Apart from playing an important role in TGFbeta1-induced CTGF expression they also act as markers of EMT in human PTECs. It also acts as an integrator of multiple signals in the regulation of NOS3 expression. It is ubiquitously expressed in most of the tissues and is responsible for colorectal, hepatocellular, lung and breast carcinomas as well as cervical cancer. |
| Immunogen | SMAD2 antibody was raised against amino acids 234 - 249 of SMAD2 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| SMAD2 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL. | |
| Species Reactivity | BatBovineChickenDogGibbonHamsterHorseHumanMonkeyMouseOrangutanRabbitRatXenopus |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | SMAD2 |
|---|---|
| Alternative Names | SMAD2 HMAD-2 HSMAD2 JV18-1 Mad protein homolog smad2 MADR2 MADH2 SMAD 2 MAD homolog 2 Mad-related protein 2 JV18 Mother against DPP homolog 2 Mothers against DPP homolog 2 Sma- and Mad-related protein 2 SMAD family member 2 |
Application
Immunohistochemistry staining of SMAD2 in placenta tissue using SMAD2 Antibody.| Application Notes | SMAD2 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | SMAD2 antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.05% BSA, 0.05% sodium azide |
