This gene encodes a member of the SPARC family (secreted
protein acidic and rich in cysteine/osteonectin/BM-40), which are
highly expressed during embryogenesis and wound healing. The gene
product is a matricellular protein which promotes matrix assembly
and can stimulate endothelial cell proliferation and migration, as
well as angiogenic activity. Associated with pulmonary function,
this secretory gene product contains a Kazal domain, two
thymoglobulin type-1 domains, and two EF-hand calcium-binding
domains. The encoded protein may serve as a target for controlling
angiogenesis in tumor growth and myocardial ischemia. Alternative
splicing results in multiple transcript variants. [provided by
RefSeq].1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Immunogen
This SMOC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 405-431 amino acids from the C-terminal region of human SMOC2.
Western blot analysis in human placenta tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.