This gene encodes a member of the Sp subfamily of Sp/XKLF
transcription factors. Sp family proteins are sequence-specific
DNA-binding proteins characterized by an amino-terminal
trans-activation domain and three carboxy-terminal zinc finger
motifs. This protein contains the least conserved DNA-binding
domain within the Sp subfamily of proteins, and its DNA sequence
specificity differs from the other Sp proteins. It localizes
primarily within subnuclear foci associated with the nuclear
matrix, and can activate or in some cases repress expression from
different promoters.1) Ito, H., et al. Biochim. Biophys. Acta 1789 (11-12), 681-690 (2009) :
Immunogen
This SP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-526 amino acids from the C-terminal region of human SP2.
Western blot analysis in mouse lung tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.