3-oxo-5-alpha-steroid 4-dehydrogenase 2, 5 alpha-SR2, SR type 2, Steroid 5-alpha-reductase 2, S5AR 2, Type II 5-alpha reductase, SRD5A2
Product description
This gene encodes a microsomal protein expressed at high
levels in androgen-sensitive tissues such as the prostate. The
encoded protein is active at acidic pH and is sensitive to the
4-azasteroid inhibitor finasteride. Deficiencies in this gene can
result in male pseudohermaphroditism, specifically pseudovaginal
perineoscrotal hypospadias (PPSH).1) Thigpen, A.E., et al. N. Engl. J. Med. 327(17):1216-1219(1992)
Immunogen
This SRD5A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the Central region of human SRD5A2.
Western blot analysis in mouse kidney tissue lysates (15ug/lane).This demonstrates the detected SRD5A2 protein (arrow).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.