Application
Western blot analysis of extracts from Jurkat cells treated with TNF using Phospho-SREBP-1 (Ser439) Antibody. The lane on the right is treated with the antigen-specific peptide.| Product Name | SREBP-1 (phospho Ser439) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SRBP1, SREBF1, SREBP1, sterol regulatory element-binding protein 1, |
| Product description | Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway By similarity. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').1) Bengoechea-Alonso MT, Ericsson J (2006) Cell Cycle 5, 1708-18 |
| Immunogen | SREBP-1 (phospho Ser439) antibody was raised against a peptide sequence around phosphorylation site of serine439 (Q-S-S (p)-P-L) derived from Human SREBP-1 . |
| Modification | p-Ser439 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000: |
|
| Species Reactivity | HumanRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SREBF1 |
|---|---|
| Alternative Names | SRBP1 SREBF1 SREBP1 sterol regulatory element-binding protein 1 |
| Molecular Weight(MW) | 122 kDa |
| Tissue Specificity | The antibody detects endogenous level of SREBP-1 only when phosphorylated at serine 439. |
| Entrez Gene | 6720 |
|---|---|
| Protein Accession | NP_001005291.1 |
Application
Western blot analysis of extracts from Jurkat cells treated with TNF using Phospho-SREBP-1 (Ser439) Antibody. The lane on the right is treated with the antigen-specific peptide.| Application Notes | Western Blot: 1:500~1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
