Application
Immunohistochemistry of TBC1D4 in human prostate tissue with TBC1D4 antibody at 10 μg/mL.| Product Name | TBC1D4 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TBC1D4 Antibody: AS160, AS160, KIAA0603, TBC1 domain family member 4, Akt substrate of 160 kDa |
| Product description | TBC1D4 Antibody: TBC1D4, also known as the Akt substrate AS160, was initially identified as an Akt substrate containing a GTPase-activating domain that regulates GLUT4 trafficking, with activation following insulin stimulation. TBC1D4 truncations in humans is a major cause of dominant inherited insulin resistance. The loss of TBC1D4 results in the accumulation of GLUT4 in compartments that are primed for fusion in basal adipocytes.1) Kane S, Sano H, Liu SCH, et al. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J. Biol. Chem. 2002; 277:22115-8. |
| Immunogen | TBC1D4 antibody was raised against an 19 amino acid peptide near the carboxy terminus of human TBC1D4 . The immunogen is located within amino acids 1190 - 1240 of TBC1D4. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-P |
| TBC1D4 antibody can be used for immunohistochemistry starting at 10 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TBC1D4 |
|---|---|
| Alternative Names | TBC1D4 Antibody: AS160 AS160 KIAA0603 TBC1 domain family member 4 Akt substrate of 160 kDa |
| Molecular Weight(MW) | Predicted: 143 kDa Observed: 140 kDa |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Mouse: (89%) |
Application
Immunohistochemistry of TBC1D4 in human prostate tissue with TBC1D4 antibody at 10 μg/mL.| Positive Control | 1) Cat. No. 10-635 - Human Prostate Tissue Slide |
|---|---|
| Application Notes | TBC1D4 antibody can be used for immunohistochemistry starting at 10 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TBC1D4 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | TBC1D4 Antibody is supplied in PBS containing 0.02% sodium azide. |
