Application
Western blot analysis in human placenta tissue lysates (35ug/lane).Application
Western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).| Product Name | TEAD2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Transcriptional enhancer factor TEF-4, TEA domain family member 2, TEAD-2, TEAD2, TEF4 |
| Product description | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) |
| Immunogen | This TEAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-295 amino acids from the Central region of human TEAD2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TEAD2 |
|---|---|
| Alternative Names | Transcriptional enhancer factor TEF-4 TEA domain family member 2 TEAD-2 TEAD2 TEF4 |
| Molecular Weight(MW) | 49 kDa |
Application
Western blot analysis in human placenta tissue lysates (35ug/lane).
Application
Western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
