Transcription factor AP-2-beta, AP2-beta, Activating enhancer-binding protein 2-beta, TFAP2B
Product description
This gene encodes a member of the AP-2 family of
transcription factors. AP-2 proteins form homo- or hetero-dimers
with other AP-2 family members and bind specific DNA sequences.
They are thought to stimulate cell proliferation and suppress
terminal differentiation of specific cell types during embryonic
development. Specific AP-2 family members differ in their
expression patterns and binding affinity for different promoters.
This protein functions as both a transcriptional activator and
repressor. Mutations in this gene result in autosomal dominant Char
syndrome, suggesting that this gene functions in the
differentiation of neural crest cell derivatives. [provided by
RefSeq].1) Li, X., et al. Genes Chromosomes Cancer 49(9):819-830(2010)
Immunogen
This TFAP2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 431-462 amino acids from the C-terminal region of human TFAP2B.
Western blot analysis in CEM cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.