This gene is a member of the transferrin receptor-like
family and encodes a single-pass type II membrane protein with a
protease associated (PA) domain, an M28 peptidase domain and a
transferrin receptor-like dimerization domain. This protein
mediates cellular uptake of transferrin-bound iron and mutations in
this gene have been associated with hereditary hemochromatosis type
III. Alternatively spliced variants which encode different protein
isoforms have been described; however, not all variants have been
fully characterized.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This TFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 674-703 amino acids from the C-terminal region of human TFR2.
Western blot analysis in NCI-H292,K562 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.