Application
Western blot analysis of TL1A in PC-3 cell lysates with TL1A antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.| Product Name | TL1A Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TL1A Antibody: TL1, TL1A, VEGI, VEGI192A, TL1, Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1 |
| Product description | TL1A Antibody: Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) is preferentially expressed by T lymphocytes and upregulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A. TL1A also binds decoy receptor DcR3/TR6, which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-κB activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI).1) Chinnayan AM, O’Rourke K, Yu GL, et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996; 274:990-2. |
| Immunogen | TL1A antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human TL1A. The immunogen is located within amino acids 60 - 110 of TL1A. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| TL1A antibody can be used for detection of TL1A by Western blot at 0.5 to 2 μg/mL.: |
|
| Species Reactivity | MouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TNFSF15 |
|---|---|
| Alternative Names | TL1A Antibody: TL1 TL1A VEGI VEGI192A TL1 Tumor necrosis factor ligand superfamily member 15 TNF ligand-related molecule 1 |
| Molecular Weight(MW) | Predicted: 28 kDa Observed: 26 kDa |
| Tissue Specificity | This polyclonal antibody will not cross-react with TL1. |
Application
Western blot analysis of TL1A in PC-3 cell lysates with TL1A antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.| Positive Control | 1) Cat. No. 1216 - PC-3 Cell Lysate |
|---|---|
| Application Notes | TL1A antibody can be used for detection of TL1A by Western blot at 0.5 to 2 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TL1A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | TL1A Antibody is supplied in PBS containing 0.02% sodium azide. |
