Application
Western blot analysis of TMEM16A in A549 cell lysate with TMEM16A antibody at 1 μg/mL.| Product Name | TMEM16A Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TMEM16A Antibody: DOG1, TAOS2, ORAOV2, TMEM16A, DOG1, Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1 |
| Product description | TMEM16A Antibody: Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC's include the transmembrane proteins TMEM16A and TMEM16B. TMEM16A is expressed in epithelial cells of the kidney and lung, pancreas, and sensory neurons and its mRNA is seen in foregut, airway epithelia, and tracheal smooth muscle; mice lacking TMEM16A fail to survive past ten days and show aerophagia and little weight gain. TMEM16A is also overexpressed or amplified in multiple cancers associated with poor survival such as oral cancers and gastrointestinal stromal tumors, suggesting the development of CaCC modulators may be a viable therapeutic strategy.1) Schroeder BC, Cheng T, Jan YN, et al. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell2008; 134:1019-29. |
| Immunogen | TMEM16A antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human TMEM16A. The immunogen is located within amino acids 70 - 120 of TMEM16A. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| TMEM16A antibody can be used for detection of TMEM16A by Western blot at 1 μg/mL.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ANO1 |
|---|---|
| Alternative Names | TMEM16A Antibody: DOG1 TAOS2 ORAOV2 TMEM16A DOG1 Anoctamin-1 Discovered on gastrointestinal stromal tumors protein 1 |
Application
Western blot analysis of TMEM16A in A549 cell lysate with TMEM16A antibody at 1 μg/mL.| Positive Control | 1) Cat. No. 1203 - A549 Cell Lysate |
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| Application Notes | TMEM16A antibody can be used for detection of TMEM16A by Western blot at 1 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TMEM16A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | TMEM16A Antibody is supplied in PBS containing 0.02% sodium azide. |
