The protein encoded by this gene is the
tropomyosin-binding subunit of the troponin complex, which is
located on the thin filament of striated muscles and regulates
muscle contraction in response to alterations in intracellular
calcium ion concentration. Mutations in this gene have been
associated with familial hypertrophic cardiomyopathy as well as
with dilated cardiomyopathy. Transcripts for this gene undergo
alternative splicing that results in many tissue-specific isoforms,
however, the full-length nature of some of these variants has not
yet been determined.1) Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
Immunogen
This TNNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182-211 amino acids from the Central region of human TNNT2.
Western blot analysis in mouse heart tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.