Application
Immunohistochemistry staining of TP53BP1 in skeletal muscle tissue using TP53BP1 Antibody.| Product Name | TP53BP1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TP53BP1, 53BP1, p202, p53-binding protein 1, p53-binding protein 53bp1, p53BP1 |
| Product description | P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability. Tumor protein p53 binding protein 1 binds to the central domain of p53 required for site-specific DNA binding thus inhibiting the ability of p53 to bind DNA. TP53BP1 also functions as a checkpoint protein with properties of a DNA double-strand break sensor. It is a putative substrate of ATM kinase and is phosphorylated in response to DNA damage and localizes to sites of double-strand breaks. |
| Immunogen | TP53BP1 antibody was raised against a synthetic peptide corresponding to the carboxy - terminus of TP53BP1 (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| TP53BP1 antibody can be used in ELISA, and immunohistochemistry starting at 5 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TP53BP1 |
|---|---|
| Alternative Names | TP53BP1 53BP1 p202 p53-binding protein 1 p53-binding protein 53bp1 p53BP1 |
Application
Immunohistochemistry staining of TP53BP1 in skeletal muscle tissue using TP53BP1 Antibody.| Application Notes | TP53BP1 antibody can be used in ELISA, and immunohistochemistry starting at 5 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store TP53BP1 antibody at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, pH 7.2, no preservatives added. |
