Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using Trk B (Phospho-Tyr706/Tyr707) antibody (left) or the same antibody preincubated with blocking peptide (right).| Product Name | Trk B (phospho Tyr706/Tyr707) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Trk-B, NTRK2, GP145-TrkB |
| Product description | Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.1) Nakagawara A., Genomics 25:538-546(1995). |
| Immunogen | Trk B (phospho Tyr706/Tyr707) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 706/tyrosine 707 (T-D-Y (p)-Y (p)-R-V)derived from Human Trk B. |
| Modification | p-Tyr706/Tyr707 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NTRK2 |
|---|---|
| Alternative Names | Trk-B NTRK2 GP145-TrkB |
| Molecular Weight(MW) | 91 kDa |
| Tissue Specificity | The antibody detects endogenous levels of Trk B only when phosphorylated at tyrosine 706 and tyrosine 707. |
| Entrez Gene | 4915 |
|---|---|
| Protein Accession | NP_001018074.1 |
Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using Trk B (Phospho-Tyr706/Tyr707) antibody (left) or the same antibody preincubated with blocking peptide (right).| Application Notes | IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
