Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance.1) Tischfield M. A., Baris H. N., Wu C., Rudolph G., Van Maldergem L., He W., Chan W. M., Andrews C., Cell 140:74-87 (2010) Katsetos C. D., Legido A., Perentes E., Mork S. J. J. Child Neurol. 18:851-866 (2003)
Immunogen
Tubulin beta-III antibody was raised against a peptide sequence around aa.442~446 (E-E-S-E-A) derived from Human Tubulin beta-III.