Tubby-related protein 3, Tubby-like protein 3, TULP3, TUBL3
Product description
This gene encodes a member of the tubby gene family of
bipartite transcription factors. Members of this family have been
identified in plants, vertebrates, and invertebrates, and they
share a conserved N-terminal transcription activation region and a
conserved C-terminal DNA and phosphatidylinositol-phosphate binding
region. The encoded protein binds to phosphoinositides in the
plasma membrane via its C-terminal region and probably functions as
a membrane-bound transcription regulator that translocates to the
nucleus in response to phosphoinositide hydrolysis, for instance,
induced by G-protein-coupled-receptor signaling. It plays an
important role in neuronal development and function. Two transcript
variants encoding distinct isoforms have been identified for this
gene.1) Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
Immunogen
This TULP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-400 amino acids from the C-terminal region of human TULP3.
Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.