This gene encodes a member of the WD repeat protein
family. WD repeats are minimally conserved regions of approximately
40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
which may facilitate formation of heterotrimeric or multiprotein
complexes. Members of this family are involved in a variety of
cellular processes, including cell cycle progression, signal
transduction, apoptosis, and gene regulation. This gene is excluded
as a candidate for a form of nonsyndromic deafness (DFNB10), but is
still a candidate for other disorders mapped to 21q22.3 as well as
for the development of Down syndrome phenotypes. Two transcript
variants encoding the same protein have been found for this gene.1) Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Immunogen
This WDR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-173 amino acids from the Central region of human WDR4.
Western blot analysis in Hela cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.