The protein encoded by this gene functions to inhibit WNT
proteins, which are extracellular signaling molecules that play a
role in embryonic development. This protein contains a WNT
inhibitory factor (WIF) domain and five epidermal growth factor
(EGF)-like domains, and is thought to be involved in mesoderm
segmentation. This gene functions as a tumor suppressor gene, and
has been found to be epigenetically silenced in various cancers.1) Licchesi, J.D., et al. Oncogene 29(44):5923-5934(2010)
Immunogen
This WIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-373 amino acids from the C-terminal region of human WIF1.
Western blot analysis in CEM cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.