Application
Western blot analysis of extracts from HepG2 cells treated with Anisomycin using Phospho-XIAP (Ser87) Antibody. The lane on the right is treated with the antigen-specific peptide.| Product Name | XIAP (phospho Ser87) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | API3, BIR4, BIRC4, IAP3, X-linked IAP |
| Product description | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state.1) Huang X, Wu Z, Mei Y, Wu M (2013)EMBO J 32, 2204-16. Bornhauser BC, et al. (2007) Blood 110, 2084-91.Dan HC, et al. (2004)J Biol Chem 279, 5405-12. |
| Immunogen | XIAP (phospho Ser87) antibody was raised against a peptide sequence around phosphorylation site of serine87 (K-V-S (p)-P-N) derived from Human XIAP . |
| Modification | p-Ser87 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | XIAP |
|---|---|
| Alternative Names | API3 BIR4 BIRC4 IAP3 X-linked IAP |
| Molecular Weight(MW) | 57 kDa |
| Tissue Specificity | The antibody detects endogenous level of XIAP only when phosphorylated at serine 87. |
| Entrez Gene | 331 |
|---|---|
| Protein Accession | NP_001158.2 |
Application
Western blot analysis of extracts from HepG2 cells treated with Anisomycin using Phospho-XIAP (Ser87) Antibody. The lane on the right is treated with the antigen-specific peptide.| Application Notes | Western Blot: 1:500~1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
