Application
Western blot analysis of ZIP6 in mouse lung tissue lysate with ZIP6 antibody at 1 μg/mL.Application
Immunofluorescence of ZIP6 in mouse lung tissue with ZIP6 antibody at 20 μg/mL.Application
Immunohistochemistry of ZIP6 in mouse lung tissue with ZIP6 antibody at 5 μg/mL.| Product Name | ZIP6 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | ZIP6 Antibody: The zinc transporter ZIP6, also known as SLC39A6, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP6 expression has also been reported in human cervical cancer and the HeLa cell line; down-regulation of ZIP6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP6 plays a regulatory role on the ERK1/2-Snail/Slug pathway.1) Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50. |
| Immunogen | ZIP6 antibody was raised against a 16 amino acid synthetic peptide near the center of human ZIP6. The immunogen is located within amino acids 430 - 480 of ZIP6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| ZIP6 antibody can be used for detection of ZIP6 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL. | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SLC39A6 |
|---|---|
| Alternative Names | ZIP6 Antibody: LIV-1 LIV1 ZIP6 Zinc transporter ZIP6 Estrogen-regulated protein LIV-1 ZIP-6 |
| Entrez Gene | 25800 |
|---|---|
| Protein Accession | NP_001092876 |
Application
Western blot analysis of ZIP6 in mouse lung tissue lysate with ZIP6 antibody at 1 μg/mL.
Application
Immunofluorescence of ZIP6 in mouse lung tissue with ZIP6 antibody at 20 μg/mL.
Application
Immunohistochemistry of ZIP6 in mouse lung tissue with ZIP6 antibody at 5 μg/mL.| Positive Control | 1) Cat. No. 1402 - Mouse Lung Tissue Lysate |
|---|---|
| Application Notes | ZIP6 antibody can be used for detection of ZIP6 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL. |
| Form | Liquid |
|---|---|
| Storage Instructions | ZIP6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | ZIP6 Antibody is supplied in PBS containing 0.02% sodium azide. |
