Application
Western blot analysis of ZIP7 in mouse brain tissue lysate with ZIP7 antibody at 0.5 μg/mL.Application
Immunofluorescence of ZIP7 in human brain tissue with ZIP7 antibody at 20 μg/mL.Application
Immunohistochemistry of ZIP7 in human brain tissue with ZIP7 antibody at 2.5 μg/mL.| Product Name | ZIP7 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | ZIP7 Antibody: The zinc transporter ZIP7, also known as SLC39A7, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP7 was initially identified while characterizing genes in the major histocompatibility complex on chromosome 17. ZIP7 mRNA is abundantly and widely expressed and the protein localizes to the Golgi apparatus. It functions to transport intracellular zinc from the Golgi apparatus to the cytoplasm of the cell. ZIP7 expression is expressed by zinc. ZIP7 has been suggested to act a hub for tyrosine kinase activation and may thus be a potential therapeutic target for diseases such as cancer where prevention of tyrosine kinase activation would be advantageous.1) Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50. |
| Immunogen | ZIP7 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human ZIP7. The immunogen is located within amino acids 20 - 70 of ZIP7. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| ZIP7 antibody can be used for detection of ZIP7 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SLC39A7 |
|---|---|
| Alternative Names | ZIP7 Antibody: KE4 HKE4 ZIP7 RING5 H2-KE4 D6S115E D6S2244E Zinc transporter SLC39A7 Histidine-rich membrane protein Ke4 |
| Sequence Similarities | 2) Cat. No. 10-301 - Human Brain Tissue Slide |
| Entrez Gene | 7922 |
|---|---|
| Protein Accession | NP_001070984 |
Application
Western blot analysis of ZIP7 in mouse brain tissue lysate with ZIP7 antibody at 0.5 μg/mL.
Application
Immunofluorescence of ZIP7 in human brain tissue with ZIP7 antibody at 20 μg/mL.
Application
Immunohistochemistry of ZIP7 in human brain tissue with ZIP7 antibody at 2.5 μg/mL.| Positive Control | 1) Cat. No. 1403 - Mouse Brain Tissue Lysate |
|---|---|
| Application Notes | ZIP7 antibody can be used for detection of ZIP7 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL. |
| Form | Liquid |
|---|---|
| Storage Instructions | ZIP7 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | ZIP7 Antibody is supplied in PBS containing 0.02% sodium azide. |
