| Product Name | F4/80 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ADGRE1 antibody Adhesion G protein coupled receptor E1 antibody Adhesion G protein-coupled receptor E1 antibody AGRE1_HUMAN antibody Cell surface glycoprotein EMR1 antibody Cell surface glycoprotein F4/80 antibody DD7A5 7 antibody Egf like module containing mucin like hormone receptor like 1 antibody Egf like module containing mucin like hormone receptor like sequence 1 antibody EGF like module receptor 1 antibody EGF TM7 antibody EGF-like module receptor 1 antibody EGF-like module-containing mucin-like hormone receptor-like 1 antibody EGFTM7 antibody EMR 1 antibody EMR1 hormone receptor antibody Gpf480 antibody Ly71 antibody Lymphocyte antigen 71 antibody |
| Product description | The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL. These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system. The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13. The F4/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin. F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation. The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rat |
| Tested Applications | IFIHC-PWB |
| WB:1:100-1:1,000 IF:1:50-500 IHC:1:50-500 FC:1 μg per 1 x 106 cells |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | ADGRE1 antibody Adhesion G protein coupled receptor E1 antibody Adhesion G protein-coupled receptor E1 antibody AGRE1_HUMAN antibody Cell surface glycoprotein EMR1 antibody Cell surface glycoprotein F4/80 antibody DD7A5 7 antibody Egf like module containing mucin like hormone receptor like 1 antibody Egf like module containing mucin like hormone receptor like sequence 1 antibody EGF like module receptor 1 antibody EGF TM7 antibody EGF-like module receptor 1 antibody EGF-like module-containing mucin-like hormone receptor-like 1 antibody EGFTM7 antibody EMR 1 antibody EMR1 hormone receptor antibody Gpf480 antibody Ly71 antibody Lymphocyte antigen 71 antibody |
|---|---|
| Molecular Weight(MW) | 160 kDa |
| Cellular Localization | Cell membrane |
| SwissProt ID | Q14246 |
|---|
| Application Notes | WB:1:100-1:1,000 IF:1:50-500 IHC:1:50-500 FC:1 μg per 1 x 106 cells |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
