WB
Western blot analysis using Interleukin 1 beta antibody against NIH 3T3 (1), K562 (2) cell lysate.IHC
Immunohistochemical analysis of paraffin-embedded Human bladder cancer tissues using Interleukin 1 beta antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissues using Interleukin 1 beta antibody with DAB staining.WB
Western blot analysis using Interleukin 1 beta antibody against Mouse brain(1),Mouse intestine(2),Mouse testes(3) tissue.| Product Name | Anti-Interleukin 1 beta antibody-HRP |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | HRP |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:200-1:2000 IHC:1:100-1:1000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | IL1B interleukin 1 beta |
|---|---|
| Gene Synonyms | IL-1 IL1F2 IL1beta IL1-BETA |
| Gene Full Name | interleukin 1 beta |
| Gene Summary | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020] |
| Molecular Weight(MW) | 31 kDa |
| Source | Rabbit |
| Cellular Localization | Cytoplasm>Cytosol. Lysosome. Secreted>Extracellular exosome. Secreted. |
| SwissProt ID | P01584 |
|---|
WB
Western blot analysis using Interleukin 1 beta antibody against NIH 3T3 (1), K562 (2) cell lysate.
IHC
Immunohistochemical analysis of paraffin-embedded Human bladder cancer tissues using Interleukin 1 beta antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissues using Interleukin 1 beta antibody with DAB staining.
WB
Western blot analysis using Interleukin 1 beta antibody against Mouse brain(1),Mouse intestine(2),Mouse testes(3) tissue.| Application Notes | WB:1:200-1:2000 IHC:1:100-1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
