| Gene Symbol |
BID
|
| Gene Synonyms |
FP497 |
| Gene Full Name |
BH3 interacting domain death agonist |
| Gene Summary |
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020] |
| Molecular Weight(MW) |
22KD |
| Cellular Localization |
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane |
