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Caspase-8 Polyclonal Antibody
Catalog Number:OM642824
OM642824
Discount Price
OM642824-100ul
1~2 Week
100ul
OM642824-50ul
50ul
OM642824-20ul
20ul
1~2 Week
Product Profile
Product Name Caspase-8 Polyclonal Antibody
Antibody Type Primary Antibodies
Immunogen Synthesized peptide derived from human Caspase-8
Key Feature
Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications ICC/IFIHCWB
WB:1:500-1:2000
IHC:1:50-1:200
ICC:1:50-1:200
Species Reactivity ChickenHumanMousePigRat
Concentration 1mg/ml
Purification Affinity purified
Target Information
Gene Symbol CASP8
Gene Synonyms CAP4
MACH
MCH5
FLICE
ALPS2B
Casp-8
Gene Full Name caspase 8
Gene Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Molecular Weight(MW) 55kDa
Cellular Localization Cytoplasm . Nucleus .
Application

WB

536 Tan X, Jin P, Feng L, et al. Protective effect of luteolin on cigarette smoke extract‑induced cellular toxicity and apoptosis in normal human bronchial epithelial cells via the Nrf2 pathway[J]. Oncology reports, 2014, 31(4): 1855-1862.

IHC

Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
Application Notes WB:1:500-1:2000
IHC:1:50-1:200
ICC:1:50-1:200
Additional Information
Form Liquid
Storage Instructions -15°C to -25°C/1 year(Do not lower than -25°C)
Storage Buffer iquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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