WB
Western blot analysis of Cytochrome P450 3A4 on human liver tissue lysate using anti-Cytochrome P450 3A4 antibody at 1/1,000 dilution.IHC
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Cytochrome P450 3A4 antibody. Counter stained with hematoxylin.| Product Name | CYP3A4 Recombinant Rabbit Monoclonal Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide within Human CYP3A4 aa 454-503 / 503. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| WB:1:500-1:1000 IHC:1:50-1:200 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | CYP3A4 |
|---|---|
| Gene Synonyms | HLP CP33 CP34 CYP3A NF-25 VDDR3 CYP3A3 P450C3 CYPIIIA3 CYPIIIA4 P450PCN1 |
| Gene Full Name | cytochrome P450 family 3 subfamily A member 4 |
| Gene Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020] |
| Alternative Names | 1 8-cineole 2-exo-monooxygenase antibody Albendazole monooxygenase antibody Albendazole sulfoxidase antibody CP33 antibody CP34 antibody CP3A4_HUMAN antibody CYP3 antibody CYP3A antibody CYP3A3 antibody CYP3A4 antibody 1 8-cineole 2-exo-monooxygenase antibody Albendazole monooxygenase antibody Albendazole sulfoxidase antibody CP33 antibody CP34 antibody CP3A4_HUMAN antibody CYP3 antibody CYP3A antibody CYP3A3 antibody CYP3A4 antibody CYPIIIA3 antibody CYPIIIA4 antibody Cytochrome P450 3A3 antibody Cytochrome P450 3A4 antibody Cytochrome P450 family 3 subfamily A polypeptide 4 antibody Cytochrome P450 HLp antibody Cytochrome P450 NF-25 antibody Cytochrome P450 subfamily IIIA polypeptide 4 antibody cytochrome P450 subfamily IIIA (niphedipine oxidase) polypeptide 3 antibody cytochrome P450 subfamily IIIA (niphedipine oxidase) polypeptide 4 antibody Cytochrome P450-PCN1 antibody Glucocorticoid inducible P450 antibody HLP antibody MGC126680 antibody NF 25 antibody NF25 antibody Nifedipine oxidase antibody P450 III steroid inducible antibody P450 PCN1 antibody P450 family III antibody P450C3 antibody P450PCN1 antibody Quinine 3 monooxygenase antibody Quinine 3-monooxygenase antibody Taurochenodeoxycholate 6 alpha hydroxylase antibody Taurochenodeoxycholate 6-alpha-hydroxylase antibody |
| Molecular Weight(MW) | 57kDa(Observed band size: 53kDa) |
| Cellular Localization | Endoplasmic reticulum membrane. Microsome membrane. |
WB
Western blot analysis of Cytochrome P450 3A4 on human liver tissue lysate using anti-Cytochrome P450 3A4 antibody at 1/1,000 dilution.
IHC
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Cytochrome P450 3A4 antibody. Counter stained with hematoxylin.| Application Notes | WB:1:500-1:1000 IHC:1:50-1:200 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
