transient receptor potential cation channel subfamily M member 7
Gene Summary
This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]
Molecular Weight(MW)
212kDa
Cellular Localization
Cell membrane,Nucleus.
Application
WB
Western blot analysis of TRPM7 expression in HeLa cell lysate.
Application Notes
WB:1:500-1:2000
Additional Information
Form
Liquid
Storage Instructions
12 months from date of receipt, -20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
Storage Buffer
500ug/ml antibody with PBS, 0.02% NaN3, 1 mg/ml BSA and 50% glycerol.