This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Molecular Weight(MW)
35kDa
Cellular Localization
Membrane.
Application
IF-P
Immunofluorescence analysis of human tonsil. 1,primary Antibody was diluted at 1:100(4~C overnight).