IHC
The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using FAM171A2 Antibody at dilution 1/40. (Original magnification: ×200)| Product Name | Anti-FAM171A2 rabbit polyclonal antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide of human FAM171A2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:20-1:100 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | FAM171A2 |
|---|---|
| Gene Full Name | family with sequence similarity 171 member A2 |
| Target | FAM171A2 is a 826 single-pass type I membrane protein belonging to the FAM171 family and is encoded by a gene located on human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair and is specifically recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. |
| Alternative Names | family with sequence similarity 171 member A2 |
| Molecular Weight(MW) | 85kDa |
| Cellular Localization | Membrane. |
IHC
The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using FAM171A2 Antibody at dilution 1/40. (Original magnification: ×200)| Application Notes | IHC:1:20-1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | -20°C. |
| Storage Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
