WB
Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-FGF Receptor 1 antibody. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody.IHC
Human kidney was stained with anti-FGF Receptor 1 Rabbit antibody.| Product Name | FGF Receptor 1 Rabbit mAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG,K |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| WB:1:2000-1:10000 IHC:1:200-1:1000 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | FGFR1 |
|---|---|
| Gene Synonyms | CEK FLG HH2 OGD ECCL FLT2 KAL2 BFGFR CD331 FGFBR FLT-2 HBGFR N-SAM FGFR-1 HRTFDS bFGF-R-1 |
| Gene Full Name | fibroblast growth factor receptor 1 |
| Gene Summary | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
| Alternative Names |
FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR Fibroblast growth factor receptor 1 FGFR-1 Basic fibroblast growth factor receptor 1 BFGFR bFGF-R-1 Fms-like tyrosine kinase 2 FLT-2 N-sam Proto-oncogene c-Fgr CD antigen CD331 |
| Molecular Weight(MW) | 92 kDa(Observed band size: 92,120,145 kDa) |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm , cytosol. Cytoplasmic vesicle. After ligand binding , both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization , or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol , and from there to the nucleus. |
WB
Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-FGF Receptor 1 antibody. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody.
IHC
Human kidney was stained with anti-FGF Receptor 1 Rabbit antibody.| Application Notes | WB:1:2000-1:10000 IHC:1:200-1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | -15°C to -25°C/1 year (Do not lower than -25°C). |
| Storage Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA. |
