WB
Western blot analysis of Kininogen 1 expression in Human platelet lysate.| Product Name | Rabbit monoclonal antibody to Kininogen 1/KNG1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | A synthesized peptide derived from human Kininogen 1. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:1000-1:5000 |
|
| Species Reactivity | Human |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KNG1 |
|---|---|
| Gene Synonyms | BK HK BDK KNG HAE6 HMWK |
| Gene Full Name | kininogen 1 |
| Gene Summary | This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2020] |
| Alternative Names | BDK Fitzgerald factor HMWK Ile Ser Bradykinin Bradykinin Kallidin I Lysyl bradykinin kininogen 1 KNG KNG1 |
| Molecular Weight(MW) | 72 kDa |
| Cellular Localization | Secreted. |
| SwissProt ID | P01042 |
|---|
WB
Western blot analysis of Kininogen 1 expression in Human platelet lysate.| Application Notes | WB:1:1000-1:5000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | 12 months from date of receipt，-20℃ as supplied. |
| Storage Buffer | 500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol. |
