Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]
Alternative Names
antigen NY-CO-9 class II histone deacetylase DKFZp779K1053 HD4 hdac-9 HDAC4 HDAC5 HDRP HDRPa histone deacetylase 4 histone deacetylase 4/5-related protein histone deacetylase 7B histone deacetylase A histone deacetylase mHDA1 histone deacetylase-related protein MEF-2 interacting transcription repressor (MITR) protein MEF2-interacting transcription repressor MITR MEF2-interacting transcriptional repressor protein deacetylase putative Type II integral membrane protein