The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Alternative Names
betagranin (N-terminal fragment of chromogranin A) catestatin cgA chromofungin chromogranin A chromogranin A (parathyroid secretory protein 1) chromogranin A precursor CTNNB DKFZp686D02253 FLJ25606 FLJ37923 MGC105435 pancreastatin parathyroid secretory protein 1 pituitary secretory protein I prohormone SP-I